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  metatag-keywords=(Syndromes Geriatriques, Neurocognitif, HTA)

  metatag-og:title=(High blood pressure predicts hippocampal atrophy rate in cognitively impaired elders. Fiford CM, et al, Alzheimers Dement (Amst) 2020.) 2020.) 2020.)

  metatag-description=(High blood pressure predicts hippocampal atrophy rate in cognitively impaired elders. Fiford CM, et al, Alzheimers Dement (Amst) 2020.) 2020.) 2020.)

  metatag-og:type=article
  metatag-article:published_time=2021-03-03
  metatag-article:modified_time=2021-03-07

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{{pmid>addtt:32587882|High blood pressure predicts hippocampal atrophy rate in cognitively impaired elders.}}
{{pmid>addhash_fr:32587882|Syndromes_Geriatriques, HTA}}

====== High blood pressure predicts hippocampal atrophy rate in cognitively impaired elders. Fiford CM, et al, Alzheimers Dement (Amst) 2020. ======

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{{tag>Syndromes_Geriatriques Neurocognitif   }}
{{tag>HTA}}
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  * **Proposé le :** 03/03/2021 11:07:03
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{{tag>Proposé_à_relecture 2021-03 Non_attribué Non_finalisé}}
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===== Résumé et points clés =====



**Introduction:** Understanding relationships among blood pressure (BP), cognition, and brain volume could inform Alzheimer's disease (AD) management.

**Methods:** We investigated Alzheimer's Disease Neuroimaging Initiative (ADNI)

**Participants:** 200 controls, 346 mild cognitive impairment (MCI), and 154 AD. National Alzheimer's Co-ordinating Center (NACC) participants were separately analyzed: 1098 controls, 2297 MCI, and 4845 AD. Relationships between cognition and BP were assessed in both cohorts and BP and atrophy rates in ADNI. Multivariate mixed linear-regression models were fitted with joint outcomes of BP (systolic, diastolic, and pulse pressure), cognition (Mini-Mental State Examination, Logical Memory, and Digit Symbol) and atrophy rate (whole-brain, hippocampus).

**Results:** ADNI MCI and AD patients with greater baseline systolic BP had higher hippocampal atrophy rates ([r, P value]; 0.2, 0.005 and 0.2, 0.04, respectively). NACC AD patients with lower systolic BP had lower cognitive scores (0.1, 0.0003). DISCUSSION: Higher late-life BP may be associated with faster decline in cognitively impaired elders.

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===== Références =====

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