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  metatag-keywords=(Vieillissement, Neurocognitif, Age Cerebral, Anxiété, Ruminations, Matière Grise)

  metatag-og:title=(Aging faster: worry and rumination in late life are associated with greater brain age. Karim HT, et al, Neurobiol Aging 2021.)

  metatag-description=(Aging faster: worry and rumination in late life are associated with greater brain age. Karim HT, et al, Neurobiol Aging 2021.)

  metatag-og:type=article
  metatag-article:published_time=2021-03-02
  metatag-article:modified_time=2021-03-07

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{{pmid>addtt:33561786|Aging faster: worry and rumination in late life are associated with greater brain age.}}
{{pmid>addhash_fr:33561786|Vieillissement, Age_Cerebral, Anxiété, Ruminations, Matière_Grise}}

====== Aging faster: worry and rumination in late life are associated with greater brain age. Karim HT, et al, Neurobiol Aging 2021. ======

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{{tag>Vieillissement Neurocognitif   }}
{{tag>Age_Cerebral, Anxiété, Ruminations, Matière_Grise}}
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  * **Proposé le :** 02/03/2021 08:07:07
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  * **Avec la version du site :** <label type="warning">**v2021_01_12**</label>
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{{tag>Proposé_à_relecture 2021-03 Non_attribué Non_finalisé}}
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===== Résumé et points clés =====

Older adults with anxiety have lower gray matter brain volume-a component of accelerated aging. We have previously validated a machine learning model to predict brain age, an estimate of an individual's age based on voxel-wise gray matter images. We investigated associations between brain age and anxiety, depression, stress, and emotion regulation. We recruited 78 participants (≥50 years) along a wide range of worry severity. We collected imaging data and computed voxel-wise gray matter images, which were input into an existing machine learning model to estimate brain age. We conducted a multivariable linear regression between brain age and age, sex, race, education, worry, anxiety, depression, rumination, neuroticism, stress, reappraisal, and suppression. We found that greater brain age was significantly associated with greater age, male sex, greater worry, greater rumination, and lower suppression. Male sex, worry, and rumination are associated with accelerated aging in late life and expressive suppression may have a protective effect. These results provide evidence for the transdiagnostic model of negative repetitive thoughts, which are associated with cognitive decline, amyloid, and tau.

===== Références de l'article =====

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===== Références =====

~~REFNOTES~~

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