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  metatag-keywords=(Iatrogénie, Effet Placebo, Neurophysiologie)

  metatag-og:title=(Meta-analysis of neural systems underlying placebo analgesia from individual participant fMRI data. Zunhammer M, et al, Nat Commun 2021.)

  metatag-description=(Meta-analysis of neural systems underlying placebo analgesia from individual participant fMRI data. Zunhammer M, et al, Nat Commun 2021.)

  metatag-og:type=article
  metatag-article:published_time=2021-03-07
  metatag-article:modified_time=2021-03-11

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{{pmid>addtt:33654105|Meta-analysis of neural systems underlying placebo analgesia from individual participant fMRI data.}}
{{pmid>addhash_fr:33654105|Iatrogénie, Effet_Placebo, Neurophysiologie}}

====== Meta-analysis of neural systems underlying placebo analgesia from individual participant fMRI data. Zunhammer M, et al, Nat Commun 2021. ======

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  * **Proposé le :** 07/03/2021 07:55:43
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===== Résumé et points clés =====

The brain systems underlying placebo analgesia are insufficiently understood. Here we performed a systematic, participant-level meta-analysis of experimental functional neuroimaging studies of evoked pain under stimulus-intensity-matched placebo and control conditions, encompassing 603 healthy participants from 20 (out of 28 eligible) studies. We find that placebo vs. control treatments induce small, widespread reductions in pain-related activity, particularly in regions belonging to ventral attention (including mid-insula) and somatomotor networks (including posterior insula). Behavioral placebo analgesia correlates with reduced pain-related activity in these networks and the thalamus, habenula, mid-cingulate, and supplementary motor area. Placebo-associated activity increases occur mainly in frontoparietal regions, with high between-study heterogeneity. We conclude that placebo treatments affect pain-related activity in multiple brain areas, which may reflect changes in nociception and/or other affective and decision-making processes surrounding pain. Between-study heterogeneity suggests that placebo analgesia is a multi-faceted phenomenon involving multiple cerebral mechanisms that differ across studies.

===== Références de l'article =====

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===== Références =====

~~REFNOTES~~

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