{{htmlmetatags>
  metatag-keywords=(Syndromes Geriatriques, Neurocognitif, Fragilité, MCI)

  metatag-og:title=(Concomitant neurodegenerative pathologies contribute to the transition from mild cognitive impairment to dementia. McAleese KE, et al, Alzheimers Dement 2021.)

  metatag-description=(Concomitant neurodegenerative pathologies contribute to the transition from mild cognitive impairment to dementia. McAleese KE, et al, Alzheimers Dement 2021.)

  metatag-og:type=article
  metatag-article:published_time=2021-03-07
  metatag-article:modified_time=2021-03-07

}}
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{{pmid>addtt:33663011|Concomitant neurodegenerative pathologies contribute to the transition from mild cognitive impairment to dementia.}}
{{pmid>addhash_fr:33663011|Syndromes_Geriatriques, Fragilité, MCI}}

====== Concomitant neurodegenerative pathologies contribute to the transition from mild cognitive impairment to dementia. McAleese KE, et al, Alzheimers Dement 2021. ======

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{{tag>Syndromes_Geriatriques Neurocognitif   }}
{{tag>Fragilité, MCI}}
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  * **Proposé le :** 07/03/2021 18:07:05
  * **Par :** [[:user:tweetuser]]
  * **Avec la version du site :** <label type="warning">**v2021_01_12**</label>
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{{tag>Proposé_à_relecture 2021-03 Non_attribué Non_finalisé}}
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===== Résumé et points clés =====



**Introduction:** The aged brain frequently exhibits multiple pathologies, rather than a single hallmark pathology (pure pathology [PurP]), ranging from low/intermediate levels of additional pathology (LowP) to mixed severe pathology (mixed SevP). We investigated the frequency of PurP, LowP, and mixed SevP, and the impact of additional LowP on cognition.

**Methods:** Data came from 670 cases from the Brains for Dementia research program. Cases were categorized into PurP, mixed SevP, or a main disease with additional LowP; 508 cases had a clinical dementia rating.

**Results:** 69.9% of cases had LowP, 22.7% had PurP, and 7.5% had mixed SevP. Additional LowP increased the likelihood of having mild dementia versus mild cognitive impairment (MCI) by almost 20-fold (odds ratio = 19.5). DISCUSSION: Most aged individuals have multiple brain pathologies. The presence of one additional LowP can significantly worsen cognitive decline, increasing the risk of transitioning from MCI to dementia 20-fold. Multimorbidity should be considered in dementia research and clinical studies.

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===== Références =====

~~REFNOTES~~

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