Low molecular weight heparin in COVID-19 patients prevents delirium and shortens hospitalization. D'Ardes D, et al, Neurol Sci 2021.
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Résumé et points clés
Background: COVID-19 patients present with delirium during their hospitalization.
Aims: To assess the incidence of delirium in hospitalized COVID-19 patients and analyze the possible association with demographic, clinical, laboratory, and pharmacological factors.
Methods: COVID-19 patients were assessed for clinical signs of delirium and administered the assessment test for delirium and cognitive impairment (4AT) and the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) scales.
Results: Out of the 56 patients of our cohort, 14 (25.0%) experienced delirium. The use of low molecular weight heparin (LMWH) (enoxaparin 1 mg/kg/daily) was less frequent in patients with delirium (p = 0.004) and was accompanied by lower C reactive protein (CRP) levels (p = 0.006).
Discussion: The use of LMWH was associated with absence of delirium, independently of comorbidities and age.
Conclusions: The use of LMWH may help preventing the occurrence of delirium in COVID-19 patients, with possible reduction of length of stay in the hospital and sequelae.
Références de l'article
- Low molecular weight heparin in COVID-19 patients prevents delirium and shortens hospitalization.
- Low molecular weight heparin in COVID-19 patients prevents delirium and shortens hospitalization.
- D'Ardes D, Carrarini C, Russo M, Dono F, Speranza R, Digiovanni A, Martinotti G, Di Iorio A, Onofrj M, Cipollone F, Bonanni L
- Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
- 2021
- Neurol Sci. 2021 Apr;42(4):1527-1530. doi: 10.1007/s10072-020-04887-4. Epub 2020 Nov 13.
- Aged, Aged, 80 and over, Anticoagulants/*therapeutic use, C-Reactive Protein/analysis, COVID-19/*complications/psychology, Cognition Disorders/etiology/psychology, Cohort Studies, Comorbidity, Confusion/psychology, Delirium/*etiology/*prevention & control/psychology, Enoxaparin/*therapeutic use, Female, Heparin, Low-Molecular-Weight/*therapeutic use, Humans, Inpatients, Length of Stay, Male, Neuropsychological Tests
- Syndromes_Geriatriques, COVID19, Traitement
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- DOI: 10.1007/s10072-020-04887-4
- PMID: 33185785
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