COVID-19 and dementia: Analyses of risk, disparity, and outcomes from electronic health records in the US. Wang Q, et al, Alzheimers Dement 2021.
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Résumé et points clés
Introduction: At present, there is limited data on the risks, disparity, and outcomes for COVID-19 in patients with dementia in the United States.
Methods: This is a retrospective case-control analysis of patient electronic health records (EHRs) of 61.9 million adult and senior patients (age ≥ 18 years) in the United States up to August 21, 2020.
Results: Patients with dementia were at increased risk for COVID-19 compared to patients without dementia (adjusted odds ratio [AOR]: 2.00 [95% confidence interval (CI), 1.94-2.06], P < .001), with the strongest effect for vascular dementia (AOR: 3.17 [95% CI, 2.97-3.37], P < .001), followed by presenile dementia (AOR: 2.62 [95% CI, 2.28-3.00], P < .001), Alzheimer's disease (AOR: 1.86 [95% CI, 1.77-1.96], P < .001), senile dementia (AOR: 1.99 [95% CI, 1.86-2.13], P < .001) and post-traumatic dementia (AOR: 1.67 [95% CI, 1.51-1.86] P < .001). Blacks with dementia had higher risk of COVID-19 than Whites (AOR: 2.86 [95% CI, 2.67-3.06], P < .001). The 6-month mortality and hospitalization risks in patients with dementia and COVID-19 were 20.99% and 59.26%, respectively.
Discussion: These findings highlight the need to protect patients with dementia as part of the strategy to control the COVID-19 pandemic.
Références de l'article
- COVID-19 and dementia: Analyses of risk, disparity, and outcomes from electronic health records in the US.
- COVID-19 and dementia: Analyses of risk, disparity, and outcomes from electronic health records in the US.
- Wang Q, Davis PB, Gurney ME, Xu R
- Alzheimer's & dementia : the journal of the Alzheimer's Association
- 2021
- Alzheimers Dement. 2021 Aug;17(8):1297-1306. doi: 10.1002/alz.12296. Epub 2021 Feb 9.
- Adolescent, Adult, Aged, Aged, 80 and over, Alzheimer Disease/complications/epidemiology, Black People, Brain Injuries, Traumatic/complications/epidemiology, COVID-19/*complications/epidemiology, Case-Control Studies, Dementia/*complications/epidemiology, Dementia, Vascular/complications/epidemiology, Demography, Electronic Health Records, Female, Healthcare Disparities, Hospitalization/statistics & numerical data, Humans, Male, Middle Aged, Retrospective Studies, Treatment Outcome, United States/epidemiology, White People, Young Adult
- Syndromes_Geriatriques, Alzheimer, COVID19, Facteur_de_Risque, Mortalité
- Liens
- Traduction automatique en Français sur Google Translate
- DOI: 10.1002/alz.12296
- PMID: 33559975
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