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Résumé et points clés
The brain systems underlying placebo analgesia are insufficiently understood. Here we performed a systematic, participant-level meta-analysis of experimental functional neuroimaging studies of evoked pain under stimulus-intensity-matched placebo and control conditions, encompassing 603 healthy participants from 20 (out of 28 eligible) studies. We find that placebo vs. control treatments induce small, widespread reductions in pain-related activity, particularly in regions belonging to ventral attention (including mid-insula) and somatomotor networks (including posterior insula). Behavioral placebo analgesia correlates with reduced pain-related activity in these networks and the thalamus, habenula, mid-cingulate, and supplementary motor area. Placebo-associated activity increases occur mainly in frontoparietal regions, with high between-study heterogeneity. We conclude that placebo treatments affect pain-related activity in multiple brain areas, which may reflect changes in nociception and/or other affective and decision-making processes surrounding pain. Between-study heterogeneity suggests that placebo analgesia is a multi-faceted phenomenon involving multiple cerebral mechanisms that differ across studies.
Références de l'article
- Meta-analysis of neural systems underlying placebo analgesia from individual participant fMRI data.
- Meta-analysis of neural systems underlying placebo analgesia from individual participant fMRI data.
- Zunhammer M, Spisák T, Wager TD, Bingel U, Placebo Imaging Consortium
- Nature communications
- 2021
- Nat Commun. 2021 Mar 2;12(1):1391. doi: 10.1038/s41467-021-21179-3.
- Adult, *Analgesia, Behavior, Brain/physiopathology, Female, Humans, Image Enhancement, *Magnetic Resonance Imaging, Male, Nervous System/*diagnostic imaging/*physiopathology, Pain/physiopathology, Placebos
- Iatrogénie, Effet_Placebo, Neurophysiologie
- Liens
- Traduction automatique en Français sur Google Translate
- DOI: 10.1038/s41467-021-21179-3
- PMID: 33654105
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