The purpose of this study was to address cognitive emotional factors (frustration intolerance beliefs, cognitive emotion regulation strategies) related to burnout among professionals caring for older persons. A sample of 202 nurses and care assistants for older people completed online questionnaires about their cognitive emotion regulation strategies, frustration intolerance beliefs, and burnout. Use of maladaptive strategies, especially self-blame and catastrophizing, predicted greater emotional exhaustion and depersonalization. Adaptive strategy use, such as refocusing on planning and positive reappraisal, was found to be linked to both lower emotional exhaustion and higher personal accomplishment. Frustration intolerance beliefs appeared to be closely associated with the emotional exhaustion and depersonalization dimensions of burnout, with higher frustration intolerance beliefs indicating a high risk of depersonalization. The present findings have several practical implications for reducing nurses' burnout based on cognitive behavioral therapy approaches, such as rational emotive behavior or mindfulness therapies.