Risk factors for recurrence in elderly patients with stage II colorectal cancer: a multicenter retrospective study. Yagyu T, et al, BMC Cancer 2022.
Notes sur les tags :
Réaliser des modifications :
Pour modifier ce document, il est nécessaire d'être connecté au site. Pour cela, assurez-vous d'avoir des identifiants valides. Si vous n'en avez pas,
contactez-nous. Pour vous connecter, cliquez sur l'icône
dans la barre de navigation.
Résumé et points clés
Background: Adjuvant chemotherapy for stage II colorectal cancer (CRC) is considered appropriate for patients with risk factors for recurrence, rather than for all patients uniformly. However, the risk factors for recurrence remain controversial, and there is limited information, especially for elderly patients. The Geriatric Nutritional Risk Index (GNRI) is widely used as a simple nutritional screening tool in the elderly and is associated with cancer prognosis and recurrence. This study aimed to investigate the risk factors for recurrence in the elderly with stage II CRC, focusing on the GNRI.
Methods: We enrolled 348 elderly patients (≥ 75 years) with stage II CRC who underwent curative resection at the Department of Surgery, Tottori University and our 10 affiliated institutions. The patients were divided into GNRI(high) (≥ 93.465) and GNRI(low) (< 93.465) groups.
Results: The GNRI(low) group showed a significantly worse overall survival (OS), cancer-specific survival (CSS), and relapse-free survival (RFS) (P < 0.001, P < 0.001, and P < 0.001, respectively). In a multivariate analysis, GNRI(low) (hazard ratio [HR]: 2.244, P < 0.001), pathologic T4 stage (HR: 1.658, P = 0.014), and moderate to severe lymphatic or venous invasion (HR: 1.460, P = 0.033) were independent factors affecting RFS. By using these three factors to score the risk of recurrence from 0 to 3 points, the prognosis was significantly stratified in terms of OS, CSS, and RFS (P < 0.001, P < 0.001, and P < 0.001, respectively). The recurrence rate for each score was as follows: 0 points, 9.8%; 1 point, 22.0%; 2 points, 37.3%; and 3 points, 61.9%.
Conclusions: GNRI(low), pathologic T4 stage, and moderate to severe lymphatic or venous invasion are high-risk factors for recurrence in the elderly with stage II CRC. The scoring system using these three factors appropriately predicted their recurrence and outcome.
Références de l'article
- Risk factors for recurrence in elderly patients with stage II colorectal cancer: a multicenter retrospective study.
- Risk factors for recurrence in elderly patients with stage II colorectal cancer: a multicenter retrospective study.
- Yagyu T, Yamamoto M, Tanio A, Hara K, Sugezawa K, Uejima C, Kihara K, Tatebe S, Kurisu Y, Shibata S, Yamamoto T, Nishie H, Shiota S, Saito H, Naka T, Sugamura K, Katano K, Fujiwara Y
- BMC cancer
- 2022
- BMC Cancer. 2022 Apr 11;22(1):390. doi: 10.1186/s12885-022-09501-8.
- Aged, *Colorectal Neoplasms/epidemiology/surgery, Geriatric Assessment, Humans, Neoplasm Recurrence, Local/epidemiology, *Nutrition Assessment, Nutritional Status, Prognosis, Retrospective Studies, Risk Factors
- Évaluation, Syndromes_Geriatriques, Syndromes_Geriatriques, Nutrition, Facteurs_de_risque
- Liens
- Traduction automatique en Français sur Google Translate
- DOI: 10.1186/s12885-022-09501-8
- PMID: 35410196
- Articles similaires
- Cité par
- Références
- Texte complet gratuit
- Twitter
- Twitter cet article (lien vers l'article)
- Twitter cet article (lien vers cette page)
Éditer la discussion
Références