Effects of an Omega-3 Supplemented, High-Protein Diet in Combination with Vibration and Resistance Exercise on Muscle Power and Inflammation in Old Adults: A Pilot Randomized Controlled Trial. Haß U, et al, Nutrients 2022.
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Résumé et points clés
Background: Inflammaging is considered to drive loss of muscle function. Omega-3 fatty acids exhibit anti-inflammatory properties. Therefore, we examined the effects of eight weeks of vibration and home-based resistance exercise combined with a whey-enriched, omega-3-supplemented diet on muscle power, inflammation and muscle biomarkers in community-dwelling old adults.
Methods: Participants were randomized to either exercise (3x/week, n = 20), exercise + high-protein diet (1.2-1.5 g/kg, n = 20), or exercise + high-protein and omega-3-enriched diet (2.2 g/day, n = 21). Muscle power (watt/m(2)) and chair rise test (CRT) time (s) were assessed via CRT measured with mechanography. Furthermore, leg strength (kg/m(2)) and fasting concentrations of inflammatory (interleukin (IL-) 6, IL-10, high-mobility group box-1 (HMGB-1)) and muscle biomarkers (insulin-like growth factor (IGF-) 1, IGF-binding protein-3, myostatin) were assessed.
Results: Sixty-one participants (70.6 ± 4.7 years; 47% men) completed the study. According to generalized linear mixed models, a high-protein diet improved leg strength and CRT time. Only IGF-1 increased with additional omega-3. Sex-specific analyses revealed that muscle power, IL-6, IL-6/IL-10 ratio, and HMGB-1 improved significantly in the male high-protein, omega-3-enriched group only.
Conclusion: Vibration and home-based resistance exercise combined with a high-protein, omega-3-enriched diet increased muscle power and reduced inflammation in old men, but not in old women. While muscle biomarkers remained unchanged, a high-protein diet combined with exercise improved leg strength and CRT time.
Références de l'article
- Effects of an Omega-3 Supplemented, High-Protein Diet in Combination with Vibration and Resistance Exercise on Muscle Power and Inflammation in Old Adults: A Pilot Randomized Controlled Trial.
- Effects of an Omega-3 Supplemented, High-Protein Diet in Combination with Vibration and Resistance Exercise on Muscle Power and Inflammation in Old Adults: A Pilot Randomized Controlled Trial.
- Haß U, Kochlik B, Herpich C, Rudloff S, Norman K
- Nutrients
- 2022
- Nutrients. 2022 Oct 13;14(20):4274. doi: 10.3390/nu14204274.
- Female, Humans, Male, Biomarkers/metabolism, *Diet, High-Protein, *Fatty Acids, Omega-3/pharmacology, HMGB Proteins/metabolism/pharmacology, Inflammation/metabolism, Insulin-Like Growth Factor I/metabolism, Interleukin-10/metabolism, Interleukin-6/metabolism, Muscle Strength, Muscle, Skeletal/metabolism, Myostatin/metabolism, Pilot Projects, *Resistance Training, Vibration, Aged
- Sans_Catégorie, Biomarqueurs
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- Traduction automatique en Français sur Google Translate
- DOI: 10.3390/nu14204274
- PMID: 36296958
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